B2200 engineswap into B2600 4x4

Ive got a 4x41995 b2600 no engine and I also have a complete 2wd 1991 b2200 my question is what problems will I have to work around swapping the f2 engine into the b2600 will the f2 block bolt up to the b2600 4x4 trans? Or is it easier to use the gearbox from the f2 and convert the thing to 2wd?

It wont bolt up unfortunately. You may also need to figure out driveshaft issues.