Hey I am doing this to mine right now!!!! What I did was cut out the whole firewall with the exception of a strip where the brake booster and steering shaft comes through, and I worked from there out and tubbed it out to what looks like could clear a 22 but I am using a booster off of a box blazer so unless they make a 22x8 I'm out of luck (LOL).I have a 350 that is mated to a 700r4. No probs whatsoever....but you will have to buy the lockup kit from Painless if you so happen to get a trans with a lockup torque conv....otherwise you'll mess up the trans! You didnt say what year s-10 but I am assuming it's a box....I have a 96 Hombre and all I had to do was have my driveshaft shortened almost three inches and I didn't even have to change the yoke because both the stock 5 spd for my year and a 700r4 have the same number of splines on the output shaft....Hope this helps...any other ques. email me...
FASTBAGDHOMBRE@aol.com